Clinical-immunological monitoring of etiological structure of idiopathic optic neuritis

Written by Povaliaeva D.A., Danilova G.P., Emanova L.P.

  UDK: 616.833.115–002–02:617.7–009 | Pages: 74–77 | Full text PDF | Open PDF 


Objective. The aim of this work is clinical-immunological monitoring with the determining of the role of herpesvirus (HPV) and chlamydial infection in etiological structure of idiopathic optic neuritis (ON).
Methods. A retrospective analysis of 45 patients (45 eyes) with acute idiopathic ON, aged 17 to 39 years. The criteria for selection of patients in the examined group is the lack of multiple sclerosis and other central nervous system diseases, acute and chronic specific infections.
Results. Immunoassay monitoring of serum showed etiological involvement of HPV in the development of idiopathic ON. Detailed immunoassay to detect specific antibodies of various classes confirmed etiological dominance in patients with idiopathic ON HSV- in the form monoinfection (51.5 %) and a virusvirus associations (26.7 %). Low avidity antibodies of class IgG at the values of avidity index less than 50 % were diagnosed in a significant number of patients with different serotypes of HPV (65.5 %) in serum.
Conclusions. Etiological participation of major serotypes of HPV was proved in 45 patients (100 % of cases) with idiopathic ON. Additional tests as a measure of avidity index significantly increase the possibility of etiologic diagnosis of idiopathic ON.

Links to authors:

D.A. Povaliaeva1, G.P. Danilova1, 2, L.P. Emanova1
1 Khabarovsk branch of S.N. Fyodorov MNTK «Eye Microsurgery» (211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation),
2 Postgraduate Institute for Public Health Workers (9 Krasnodarskaya St. Khabarovsk 680000 Russian Federation)

1. Ajavi Sh.M., Volik E.I., Ajavi S.M. Modern methods of treatment of posterior uveitis of virus, chlamydia, toxoplasmosis etiology // Kuban Research Medical Journal. 2005. No. 3–4. P. 54–57.
2. Gulyamova M.D., Rizopulu A.P., Kamilov H.M. [et al.]. Immunological characteristic of patients with chronic uveitis of herpetic and cytomegalovirus genesis // Medical Immunology. 2005. No. 7 (5–6). P. 543–550.
3. Egorov V.V., Ten Y.E., Danilova L.P. [et al.]. The prospect of local corticosteroid pulse-therapy in treatment of patients with idiopathic optic neuritis // Healthcare of the Far East. 2014. No. 3. P. 57–59.
4. Ermakova N.A. Classification and clinical evaluation of uveitis // Russian Medical Journal. Clinical Ophthalmology. 2003. No. 4. P. 146–149.
5. Ermakova N.A. Common understanding of the pathogenesis of uveitis // Russian Medical Journal. Clinical Ophthalmology. 2003. No. 4. P. 141–143.
6. Zavalishin I.A., Zakharova M.N. Multiple sclerosis: modern aspects of the etiology and pathogenesis // Journal of Neurology and Psychiatry. 2003. Vol. 103, No. 2. P. 10–17.
7. Kazmirchuk V.E., Maltsev D.V. Modern methods of laboratory diagnosis of herpes infections. Part 2: The clinic, diagnosis and treatment of human herpesvirus infections: a monograph. Kiev: Phoenix, 2009. 248 p.
8. Kalyuzhin O.V., Dikinov Z.H., Evsegneeva I.V. Immune mechanisms of experimental uveoretinitis // Kursk scientific-practical journal “Man and his health”. 2011. No. 1. P. 153–159.
9. Kalyuzhin O.V., Dikinov Z.H., Evsegneeva I.V. Models of intraocular inflammation // Immunopathology, Allergology, Infectology. 2011. No. 2. P. 14–19.
10. Clinical practice guidelines. Ophthalmology / ed. L.K. Moshetova, A.P. Nesterov, E.A. Egorov. Moscow, 2006. 237 p.
11. Libman E.S., Shakhova E.V. Blindness and disability due to eye pathology in Russia // Annals of Ophthalmology. 2006. No. 1. P. 35–37.
12. Neroev V.V., Karlova I.Z., Boyko A.N. Clinical features of optic neuritis, and changes in the local immune response in patients with multiple sclerosis // Journal of Neurology and Psychiatry. 2004. Vol. 104, No. 9. P. 24–26.
13. Obryadina A.P., Kopnina E.O. Antibodies avidity in the diagnosis of infectious diseases // Laboratory Diagnostics of Infectious Diseases. 2007. No. 4. P. 3–5.
14. Pashanina T.P., Napalkova G.M., Korsakova I.I. Method for determining antibody titers by immunoassay in diagnosis of viral infections // RU patent 2212038. Publ. September 10, 2003.
15. De Mello V.B., Foureaux E.C., Porto F.B. Herpes zoster optic neuritis // Int. Ophthalmol. 2011. Vol. 31, No. 3. P. 233–236. doi:


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.