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Complex impact of medico-social and environmental risk factors on probability of colorectal cancer development

Written by Feldblyum I.V., Alyeva M.H., Radionova M.V.

  UDK: 616.351–006.4–036.22 | Pages: 24–28 | Full text PDF | Open PDF 

Annotation:

Objective. We analyzed the complex impact of medico-social and environmental risk factors on probability of colorectal cancer development.
Methods. The epidemiological analytical sampling analysis ‘casecontrol’ was carried out. The group ‘case’ included 204 patients with colorectal cancer (79 patients with colon cancer, 125 – with rectum cancer). The medico-social and environmental risk factors were assessed with survey questionnaire (patterned interview).
Results. A binary choice model shows that the most significant factors, increasing the probability of colorectal cancer development with combined impact on population, were spicy food intake, polyposis of large intestine, duration of constipation; factors decreasing the probability of colorectal cancer were boiled tap water intake and frequent medical examinations. At the 5 % level, factors such as age, the presence of precancerous diseases and relatives of the 1st and/or 2nd degree of kinship with malignant neoplasms of the gastrointestinal tract or the reproductive system demonstrated significance. With an increase in age by one year, the probability of developing colorectal cancer increased by 1.5 %. The total results of the combined impact of studied factors showed that the incidence of colorectal cancer by 56.4 % was determined by above-mentioned risk factors.
Conclusions. Determined associations of medico-social and environmental factors require in-depth study to identify additional risk factors and their interactions with genetic determinants in order to develop a primary prevention system of colorectal cancer.

Links to authors:

I.V. Feldblyum1, M.H. Alyeva1, M.V. Radionova2
1 Perm State Medical University named after Academician E.A. Wagner (26 Petropavlovskaya St. Perm 614990 Russian Federation),
2 National Research University Higher School of Economics (15 Bukireva St. Perm 614012 Russian Federation)


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