Role of Streptococcus pneumoniae in the etiology of community-acquired pneumonia in a large industrial region of the Russian Federation

Written by Golubkova A.A., Somova A.V.

  UDK: 616.24–002-022:579.862.1–036.22(574.11) | Pages: 29–33 | Full text PDF | Open PDF 


Objective. Study objective is to analyze the features of epidemiological process of community-acquired pneumonia and the role of separate serotypes of Streptococcus pneumoniae in the etiology.
Methods. We used the data of state statistical reports for 2006– 2016. To assess the role of S. pneumoniae in the etiology of community- acquired pneumonia we conducted epidemiological study using molecular and genetic methods of diagnostics of pneumonia in two cities of the region with participation of 957 patients.
Results. It was determined that Sverdlovsk region is a contamination zone of community-acquired pneumonia with long-term annual average of incidence rate of 517.6 per 100 000 population. The highest level of incidence rate was registered among children under 6 y.o. and adults over 60 y.o. It was separated 167 DNA of S. pneumoniae. The most significant serotypes from 15 serogroups in developing of community-acquired pneumonia were 14, 6 A/B/C/D, 15 A/F and 19F.
Conclusions. To control the epidemic situation for communityacquired pneumonia, continuous monitoring of the circulating serotypes of the pathogen and optimization of the composition of the pneumococcal serotypes entering the vaccine against pneumococcal infection are necessary. The tactics of vaccinating children against pneumococcal infection requires further improvement, in terms of immunizing not only the children of the first year of life in the National calendar of preventive vaccinations, but also the “catch-up” immunization of all the unvaccinated until the age of 17.

Links to authors:

A.A. Golubkova1, A.V. Somova2
1 Ural State Medical University (3 Repina St. Ekaterinburg 620028 Russian Federation),
2 The Center for Hygiene and Epidemiology in the Sverdlovsk Region (3 Otdelnyi St. Ekaterinburg 620078 Russian Federation)

1. Kozlov R.S., Chagaryan A.N., Kozlova L.V., Muravyov A.A. Serological characteristics and sensitivity to antibiotics of pneumococci isolated in children under 5 years in certain regions of the Russian Federation // Klin. Microbiol. Antimicrob. Chemother. 2011. Vol. 13, No. 2. P. 177–187.
2. Korovkina E.S. Consequences of community-acquired pneumoniae and the possibility of their prevention // Pulmonology. No. 1. P. 101–105.
3. Leschenko I.V. Clinical and organizational algorithm for managing patients with community-acquired pneumoniae: Guidelines. Ekaterinburg: Elikon-design, 2012. 70 p.
4. Lobzin Y.V., Sidorenko S.V., Harit S.M. [et al.]. Serotypes of Streptococcus pneumoniae causing leading nosological forms of pneumococcal infections // Journal of Infectology. 2013. No. 4. P. 35–41.
5. Somova A.V., Romanenko V.V., Golubkova A.A. Epidemiology of S. pneumoniae- associated pneumonias and analysis of the effectiveness of vaccination against pneumococcal infection in children under the age of six // Epidemiology and Vaccinoprophylaxis. 2018. No. 1. P. 25–32.
6. Chuchalin A.G. Pneumonia: an urgent problem of medicine of the XXI century // Pulmonology. 2015. No. 2. P. 133–142.
7. Torres A., Peetermans W.E., Viegi G., Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review // Thorax. 2013. Vol. 68, No. 11. P. 1057–1065.
8. Weekly Epidemiological Records. 2012, Vol. 87, No. 14. P. 129–144.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.