Deficit deepening of naive T-cells CD4+ in patients with HIV infection when co-infected with hepatitis C virus

Written by Shmagel K.V., Korolevskaya L.B., Saydakova E.V., Shmagel N.G.

  UDK: 616–097:578–06:616–002:612.017.1 | Pages: 15–19 | Full text PDF | Open PDF 


Objective. In patients infected with the human immunodeficiency virus (HIV) and co-infected with the hepatitis C virus (HCV), CD4+ T-cell deficiency is more pronounced compared to HIV monoinfected subjects, due to a reduction in their naive subpopulation. This work is devoted to establishing the causes of the development of insufficiency of these cells.
Methods. Two groups of HIV-infected persons were examined: HIV+HCV+ (n=21) and HIV+HCV– (n=21) receiving antiretroviral drugs for more than two years (HIV level <50 copies/ml). Anti- HCV therapy was not conducted. The control group (n=20) consisted of uninfected volunteers. The number of naive CD4+ T cells, the proportion of these included RTE (recent thymic emigrants; CD31+), the content of activated CD4+ T-lymphocytes (HLA-DR+ CD38+), the concentration in the blood of bacterial lipopolysaccharide, the activity of transaminases.
Results. Immune activation negatively affected the number of naive CD4+ T cells in both groups of HIV-infected. However, only in the HIV+HCV+ group the inverse relationship between the activity of transaminases, on the one hand, and the proportion of RTE on the other hand (RALT-RTE =–0.590, p<0.005 and RASTRTE=– 0.468, p<0.05), and also the level of lipopolysaccharide and the number of mature (CD31–) naive CD4+ T-lymphocytes (R =–0.535, p<0.02).
Conclusions. Thus, hepatitis activity and increased microbial translocation from the intestine in HIV/HCV co-infection may have a negative effect on the number of naive CD4+ T cells. Naive elements of varying degrees of maturity are apparently affected. Specific mechanisms for the formation of a deficit of naive CD4+ T-lymphocytes in HIV/HCV-co-infected individuals have yet to be established.

Links to authors:

K.V. Shmagel1, L.B. Korolevskaya1, E.V. Saydakova1, N.G. Shmagel1, 2
1 Perm Scientific Centre of the Ural Branch of the Russian Academy of Sciences (13 Goleva St. Perm 614081 Russian Federation),
2 AIDS Prevention Centre (21 Arhitektora Sviyazeva St. Perm 614088 Russian Federation)

1. Cianci R., Pinti M., Nasi M. [et al.]. Impairment of recent thymic emigrants in HCV infection // Int. J. Immunopathol. Pharmacol. 2005. Vol. 18, No. 4. P. 723–728.
2. Funderburg N., Luciano A.A., Jiang W. [et al.]. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis // PLoS One. 2008. Vol. 3. P. e1915.
3. Hartling H.J., Gaardbo J.C., Ronit A. [et al.]. Impaired thymic output in patients with chronic hepatitis C virus infection // Scand. J. Immunol. 2013. Vol. 78, No. 4. P. 378–386.
4. Hunt P.W., Sinclair E., Rodriguez B. [et al.]. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection // J. Infect. Dis. 2014. Vol. 210, No. 8. P. 1228–1238.
5. Kohler S., Thiel A. Life after the thymus: CD31+ and CD31– human naive CD4+ T-cell subsets // Blood. 2009. Vol. 113, No. 4. P. 769–774.
6. Korolevskaya L.B., Shmagel K.V., Saidakova E.V. [et al.]. Effect of hepatitis C virus coinfection on the content of CD4(+) and CD8(+) T cell subpopulations in HIV-infected patients receiving antiretroviral therapy // Bull. Exp. Biol. Med. 2016. Vol. 161, No. 2. P. 281–283.
7. Potter M., Odueyungbo A., Yang H. [et al.]. Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy // AIDS. 2010. Vol. 24. No. 12. P. 1857–1865.
8. Saidakova E.V., Korolevskaya L.B., Shmagel N.G. [et al.]. Role of hepatitis C virus coinfection in violation of productive thymic function in HIV-infected patients under immunologically inefficient antiretroviral therapy // Med. Immunology (Rus.). 2013. Vol. 15, No. 6. P. 543–552.
9. Santin M., Mestre M., Shaw E. [et al.]. Impact of hepatitis C virus coinfection on immune restoration during successful antiretroviral therapy in chronic human immunodeficiency virus type 1 disease // Eur. J. Clin. Microbiol. Infect. Dis. 2008. Vol. 27, No. 1. P. 65–73.
10. Shmagel K.V., Saidakova E.V., Shmagel N.G. [et al.]. Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection // HIV Med. 2016. Vol. 17, No. 8. P. 581–589.
11. Taye S., Lakew M. Impact of hepatitis C virus co-infection on HIV patients before and after highly active antiretroviral therapy: an immunological and clinical chemistry observation, Addis Ababa, Ethiopia // BMC Immunol. 2013, Vol. 14. doi:
12. Yonkers N.L., Sieg S., Rodriguez B., Anthony D.D. Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic hepatitis C virus infection // J. Infect. Dis. 2011. Vol. 203, No. 5. P. 635–645.


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