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Deficit deepening of naive T-cells CD4+ in patients with HIV infection when co-infected with hepatitis C virus

Written by Shmagel K.V., Korolevskaya L.B., Saydakova E.V., Shmagel N.G.

  UDK: 616–097:578–06:616–002:612.017.1 | Pages: 15–19 | Full text PDF | Open PDF 

Annotation:

Objective. In patients infected with the human immunodeficiency virus (HIV) and co-infected with the hepatitis C virus (HCV), CD4+ T-cell deficiency is more pronounced compared to HIV monoinfected subjects, due to a reduction in their naive subpopulation. This work is devoted to establishing the causes of the development of insufficiency of these cells.
Methods. Two groups of HIV-infected persons were examined: HIV+HCV+ (n=21) and HIV+HCV– (n=21) receiving antiretroviral drugs for more than two years (HIV level <50 copies/ml). Anti- HCV therapy was not conducted. The control group (n=20) consisted of uninfected volunteers. The number of naive CD4+ T cells, the proportion of these included RTE (recent thymic emigrants; CD31+), the content of activated CD4+ T-lymphocytes (HLA-DR+ CD38+), the concentration in the blood of bacterial lipopolysaccharide, the activity of transaminases.
Results. Immune activation negatively affected the number of naive CD4+ T cells in both groups of HIV-infected. However, only in the HIV+HCV+ group the inverse relationship between the activity of transaminases, on the one hand, and the proportion of RTE on the other hand (RALT-RTE =–0.590, p<0.005 and RASTRTE=– 0.468, p<0.05), and also the level of lipopolysaccharide and the number of mature (CD31–) naive CD4+ T-lymphocytes (R =–0.535, p<0.02).
Conclusions. Thus, hepatitis activity and increased microbial translocation from the intestine in HIV/HCV co-infection may have a negative effect on the number of naive CD4+ T cells. Naive elements of varying degrees of maturity are apparently affected. Specific mechanisms for the formation of a deficit of naive CD4+ T-lymphocytes in HIV/HCV-co-infected individuals have yet to be established.

Links to authors:

K.V. Shmagel1, L.B. Korolevskaya1, E.V. Saydakova1, N.G. Shmagel1, 2
1 Perm Scientific Centre of the Ural Branch of the Russian Academy of Sciences (13 Goleva St. Perm 614081 Russian Federation),
2 AIDS Prevention Centre (21 Arhitektora Sviyazeva St. Perm 614088 Russian Federation)


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