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Morphometric characteristics of acroteric villi in case of placenta infection by pathogens of intrauterine infections

Written by Ostrovskaya O.V., Kozharskaya O.V., Suprun S.V., Musatov D.V., Obuhova V.G., Ivakhnishina N.M., Nagovitsina E.B., Vlasova M.A., Lebed'ko O.A.

  UDK: 618.36–002–06:616.9]–076:611.013.84| Pages: 29–33 | Full text PDF | Open PDF 

Annotation:

Objective. The study objective is the morphometric characterization of acroteric villi in the infection of placenta from premature births with pathogens of prenatally significant infections.
Methods. 34 placentas were studied after premature birth. A molecular genetic analysis was conducted; a histological and morphometric study was performed. The villi were counted in each field of view, their area, perimeter, horizontal and vertical dimensions, number of capillaries and their distance to syncytiotrophoblast were measured.
Results. In 55.9 % placenta, genomes of intrauterine infections have been identified, including the DNA of Ureaplasma spp., Mycoplasma hominis, Mycoplasma genitalium, Streptococcus agalactiae, Cytomegalovirus, Herpes human virus type 4. In infected placentas, inflammatory processes (placenta, chorioamnionitis, deciduit, villusitis) are defined in 89.5 % of cases. Morphometric parameters of acroteric villus infected placenta were characterized by a decrease in vascular content and an increase in the distance of the vessels from syncytiotrophoblast (which indicated a decrease in gas exchange and developing hypoxia), as well as an increase in compensatory-adaptive reactions aimed at expanding the gas exchange area and improving the viability of the fetus. Conclusion. The use of morphometric characteristics of acroteric villi facilitates the discovery of mechanisms for the pathogenesis of intrauterine placenta damage and the formation of miscarriages, improving the prognosis of the newborn's condition.

Links to authors:

O.V. Ostrovskaya¹, O.V. Kozharskaya², S.V. Suprun¹, D.V. Musatov², V.G. Obuhova², N.M. Ivakhnishina¹, E.B. Nagovitsina¹, M.A. Vlasova¹, O.A. Lebed'ko¹
1 Research Institute of Mother and Child Health Care – Khabarovsk Branch of Far Eastern Research Center of Respiratory Physiology and Pathology (49/1 Voronezhskaya St. Khabarovsk 680022 Russian Federation),
2 Perinatal Center (85 Istomina St. Khabarovsk 680028 Russian Federation)


1. Bulgacevich T.B., Kulaev I.A., Bryukhina E.V. Placental morphology specifics in intrauterine infection // Pulmonology. 2008. No. 13. P. 128–132.
2. Dyatlova L.I., Gerasimov V.N. Ultrastructural specifics of uterineplacental region in pregnancy complicated by chorioamnionitis // Health and Education Millennium. 2016. Vol. 1, No. 2. P. 181–188.
3. Ivahnishina N.M., Kozharskya O.V., Ostrovskaya O.V. [et al.]. Placental infection in habitual miscarriage // Bulletin FPD. 2015. No. 56. P. 88–93.
4. Lutsenko M.T., Andrievskaya I.A. Morphometric researches fetoplacentar of the barrier of villus of the placenta at herpes and cytomegalovirus infections // The Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2010. Vol. 30, No. 3. P. 137–140.
5. Ostrovskaya O.V., Ivahnishina N.M., Vlasova M.A. [et al.]. Method to detect intrauterine infectious agents in autopsy material of lost fetuses and newborns: Recommended methods. Khabarovsk: Arno, 2012. 23 p.
6. Tyutynnik V.L. Prepregnancy care, management of pregnancy, labor and postpartum period in infections // Obstetrics and Gynecology. 2004. No. 3. P. 54–57.
7. Uelina G.A., Rymashevskiy A.N. Morphological and microbiological correlation of afterbirth infection pathways in antenatal fetal death // Modern Problems of Science and Education. 2012. No. 6. P. 252–258.
8. Charnyy A.M., Kirichenko A.K., Bazina M.I. Diagnostic pathology of afterbirth diseases: Recommended methods. Moscow, 2001. 18 p.
9. Schegolev A.I., Dubova E.A., Pavlov K.A. [et al.]. Morphological description of placental terminal villi in preeclampsia // Bulletin of Experimental Biology and Medicine. 2012. Vol. 154, No. 7. P. 104–107.
10. Schegolev A.I., Lyapin V.M., Tumanova U.N. [et al]. Histological changes in the placenta and vascularization of its villi in early- and late-onset preeclampsia // Archive of Pathology. 2016. No. 1. P. 13–19.
11. Bae G.E., Yoon N., Choi M. [et al.]. Acute placental villinis as evidence of fetal sepsis: An autopsy case report // Pediatr. Dev. Pathol. 2016. Vol. 19, No. 2. P. 165–168.
12. De Freitas L.B., Pereira C.C., Mercon-de-Vargas P.R., Spano L.C. Human papillomavirus in foetal and maternal tissues from miscarriage cases // J. Obstet. Gynaecol. 2018. Vol. 8. doi:
10.1080/01443615.2018.1454408.
13. Kim C.J., Romero R., Chaemsaaithong P., Kim J.S. Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance // Am. J. Obstet. Gynecol. 2015. Vol. 213 (4 Suppl). doi:10.1016/j.ajog.2015.08.041.
14. Pereira L., Tabata T., Petitt M., Fang-Hoover J. Congenital cytomegalovirus infection undermines early development and functions of the human placenta // Placenta. 2017. Vol. 59, No.1. doi:10.1016/j.placenta. 2017.04.020.

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