Home

Immune complexes and their role in activation of immunity in HIV‑infection

Written by Korolevskaya L.B., Saydakova E.V., Shmagel K.V., Shmagel N.G.

  UDK: 616–097:578:612.017.1 | Pages: 41–45 | Full text PDF | Open PDF 

Annotation:

Objective. Immune activation is the main predictor of the progression of infection caused by the human immunodeficiency virus (HIV). The reasons remain incomprehensible and, probably, can be multifactorial. We suggest that immune complexes are also capable of stimulating immunocompetent cells.
Methods. We examined 30 HIV-infected patients who had concentrations of circulating immune complexes and the relative amount of activated T-lymphocytes. In vitro interaction of mononuclear cells of peripheral blood of uninfected donors with immune complexes containing HIV-antigens and antiviral antibodies.
Results. It was found that the concentration of circulating immune complexes is directly related to the activation of T-lymphocytes. It has been shown that the interaction of mononuclear cells of healthy donors with immune complexes leads to a significant increase in the proportion of CD14+ monocytes producing interleukin- 6 and to enhance the production of reactive oxygen species.
Conclusions. Immune complexes containing HIV-antigens and antiviral antibodies are able to activate immunocompetent cells. Such complexes may be another factor in the activation of immunity in HIV-infection.

Links to authors:

L.B. Korolevskaya1, E.V. Saydakova1, K.V. Shmagel1, N.G. Shmagel1, 2
1 Perm Scientific Centre of the Ural Branch of the Russian Academy of Sciences (13 Goleva St. Perm 614081 Russian Federation),
2 AIDS Prevention Centre (21 Arhitektora Sviyazeva St. Perm 614088 Russian Federation)


1. Anderson C.F., Mosser D.M. A novel phenotype for an activated macrophage: the type 2 activated macrophage // J. Leuk. Biology. 2002. Vol. 72, No. 1. P. 101–106.
2. Bastidas S., Graw F., Smith M.Z. [et al.]. CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals // J. Immunol. 2014. Vol. 192, No. 4. P. 1732–1744.
3. Biancotto A., Grivel J.C., Iglehart S.J. [et al.]. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1 // Blood. 2007. Vol. 109, No. 10. P. 4272–4279.
4. Brenchley J.M., Price D.A., Schacker T.W. [et al.]. Microbial translocation is a cause of systemic immune activation in chronic HIV infection // Nat. Med. 2006. Vol. 12, No. 12. P. 1365–1371.
5. Catalfamo M., Wilhelm C., Tcheung L. [et al.]. CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7 // J. Immunol. 2011. Vol. 186, No. 4. P. 2106–2116.
6. Eggena M.P., Barugahare B., Jones N. [et al.]. Depletion of regulatory T cells in HIV infection is associated with immune activation // J. Immunol. 2005. Vol. 174, No. 7. P. 4407–4414.
7. Garcia-Garcia E., Rosales C. Fc receptor signaling in leukocytes: Role in host defense and immune regulation // Current Immunology Reviews. 2009. Vol. 5. P. 227–242.
8. Guilliams M., Bruhns P., Saeys Y. [et al.]. The function of Fcgamma receptors in dendritic cells and macrophages // Nat. Rev. Immunol. 2014. Vol. 14, No. 2. P. 94–108.
9. Hazenberg M.D., Otto S.A., van Benthem B.H. [et al.]. Persistent immune activation in HIV-1 infection is associated with progression to AIDS // AIDS. 2003. Vol. 17, No. 13. P. 1881–1888.
10. Kuri-Cervantes L., de Oca G.S., Avila-Rios S. [et al.]. Activation of NK cells is associated with HIV-1 disease progression // J. Leukoc. Biol. 2014. Vol. 96, No. 1. P. 7–16.
11. Liu P., Overman R.G., Yates N.L. [et al.]. Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection // J. Virol. 2011. Vol. 85, No. 21. P. 11196–11207.
12. Moir S., Fauci A.S. B cells in HIV infection and disease // Nat. Rev. Immunol. 2009. Vol. 9, No. 4. P. 235–245.
13. Paiardini M., Muller-Trutwin M. HIV-associated chronic immune activation // Immunological Reviews. 2013. Vol. 254. P. 78–101.
14. Rosales C. Fc-gamma receptor heterogeneity in leukocyte functional responses // Front. Immunol. 2017. Vol. 8. P. 280.
15. Tanaka M., Krutzik S.R., Sieling P.A. [et al.]. Activation of Fc RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses // J. Immunol. 2009. Vol. 183. P. 2349–2355.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.