Immune complexes and their role in activation of immunity in HIV‑infection

Written by Korolevskaya L.B., Saydakova E.V., Shmagel K.V., Shmagel N.G.

  UDK: 616–097:578:612.017.1 | Pages: 41–45 | Full text PDF | Open PDF 


Objective. Immune activation is the main predictor of the progression of infection caused by the human immunodeficiency virus (HIV). The reasons remain incomprehensible and, probably, can be multifactorial. We suggest that immune complexes are also capable of stimulating immunocompetent cells.
Methods. We examined 30 HIV-infected patients who had concentrations of circulating immune complexes and the relative amount of activated T-lymphocytes. In vitro interaction of mononuclear cells of peripheral blood of uninfected donors with immune complexes containing HIV-antigens and antiviral antibodies.
Results. It was found that the concentration of circulating immune complexes is directly related to the activation of T-lymphocytes. It has been shown that the interaction of mononuclear cells of healthy donors with immune complexes leads to a significant increase in the proportion of CD14+ monocytes producing interleukin- 6 and to enhance the production of reactive oxygen species.
Conclusions. Immune complexes containing HIV-antigens and antiviral antibodies are able to activate immunocompetent cells. Such complexes may be another factor in the activation of immunity in HIV-infection.

Links to authors:

L.B. Korolevskaya1, E.V. Saydakova1, K.V. Shmagel1, N.G. Shmagel1, 2
1 Perm Scientific Centre of the Ural Branch of the Russian Academy of Sciences (13 Goleva St. Perm 614081 Russian Federation),
2 AIDS Prevention Centre (21 Arhitektora Sviyazeva St. Perm 614088 Russian Federation)

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