Analysis of matrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinases type 1 (TIMP-1) and MMP‑9/TIMP‑1 complex in patients with acute myocardial infarction after percutaneous coronary interventions

Written by Grachev N.I., Krasnikov V.E., Turmova E.P., Markelova E.V., Rublev V.Yu, Nazarenko S.A.

  UDK: 616–005.8–089.819.843–089.168.1–06:616.153.96 | Pages: 45–48 | Full text PDF | Open PDF 


Objective. The objective of the study was to identify additional markers of complications of percutaneous coronary interventions in patients with acute myocardial infarction
Methods. We analyzed the serum content MMP-9, TIMP-1, and MMP- 9/TIMP-1 complex in 86 patients aged 41–74 with acute myocardial infarction before and after percutaneous coronary intervention.
Results. The serum levels of MMP-9 and TIMP-1 in patients with acute myocardial infarction are significantly higher than in healthy individuals, while the MMP-9/TIMP-1 complex, in contrast, is lower than in the control group. The dynamics of serum concentration of MMP-9 and TIMP-1 after the intervention had a different picture: by the 7th day, the level of MMP-9 increased, while the TIMP-1 values, on the contrary, decreased.
Conclusions. Our study proved the possibility of using the serum concentration of MMP-9 (426.8–978.4 ng/ml) as a predictor of early postoperative complications in patients with acute myocardial infarction after percutaneous coronary interventions.

Links to authors:

N.I. Grachev1, V.E. Krasnikov1, E.P. Turmova1, E.V. Markelova1, V.Yu. Rublev2, S.A. Nazarenko1
1 Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690002 Russian Federation),
2 Primorye Regional Clinical Hospital No. 1 (57 Aleutskaya St. Vladivostok 690091 Russian Federation)

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