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The state of mucosal immunity in patients with periodontitis

Written by Golitsyna A.A., Yugay Yu.V., Pervov Yu.Yu., Klimkina T.N., Kovalchuk V.K.

  UDK: 616.314.17–008.1:612.017.1 | Pages: 60–62 | Full text PDF | Open PDF 

Annotation:

Objective. With the violation of mucosal immunity, the development of chronic generalized periodontitis is associated, which occupies one of the leading places in the structure of dental diseases. Of great interest are the immunological aspects of the formation of periodontal pathology in conditions of violations of carbohydrate metabolism.
Methods. 65 patients were examined, including: 30 patients – 1st group and 35 patients –2nd group. The control group consisted of healthy volunteers (30 people). Levels of TNFα, INFγ, IL-4, IL-13 and sIgA were determined by the sandwich version of the enzyme- linked immunosorbent assay. The statistical processing of the material was carried out using the SPSS v 16 program.
Results. Significant increases in TNFα, INFγ, IL-4 and IL-13 levels were registered in both groups of patients, as well as a decrease in sIgA concentrations. In patients with periodontitis without concomitant pathology, hyperproduction of TNFα and a deficiency of sIgA have been established. In the group of patients suffering from periodontitis against the background of type II diabetes, a more significant increase in IL-4 and IL-13 was revealed.
Conclusions. the obtained results of the study testify to the clinically significant insolvency of both congenital and adaptive humoral immunity, characterized by a violation of the cytokine balance and hypo production of sIgA, which causes weakening of the local immune defense of the oral cavity.

Links to authors:

A.A. Golitsyna, Yu.V. Yugay, Yu.Yu. Pervov, T.N. Klimkina, V.K. Kovalchuk
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690002 Russian Federation)


1. Biktimerova O.O., Redinova T.L., Zorin A.Yu. Changes in clinical and immunological parameters of the oral cavity in patients with chronic generalized periodontitis in the treatment of probiotics // Pacific Medical Journal. 2014. No. 3. P. 34–36.
2. Zhurbenko V.A., Yudina S.M. The effect of ozonotherapy on the state of mucosal immunity of the oral cavity in chronic periodontitis // Kursk Scientific and Practical Herald “The Man and His Health”. 2013. No. 4. P. 73–77.
3. Zyryanov B.N. Dental markers of the oral cavity in type 2 diabetes mellitus in middle-aged people // Young Scientist. 2014. No. 3. P. 178–181.
4. Kozodaeva M.V., Ivanova E.V., Manulov B.М. Condition of periodontal disease in patients with diabetes mellitus (review) // Parodontology. 2012. No. 1. P. 3–7.
5. Kulakov A.A., Zorina O.A., Boriskina Sh.A. The role of protective factors in the pathogenesis of inflammatory periodontal diseases // Stomatology. 2010. No. 6. P. 72–77.
6. Malyzhik L.P., Pinelis Yu.I., Malezhik M.S. Some aspects of immune reactions in chronic generalized periodontitis in elderly people // Dentistry. 2011. No. 6. P. 8–10.
7. Patrusheva M.S., Mikhalchenko V.F., Yakovleva A.T. Evaluation of the cytokine profile and activity of gingival fluid enzymes in Volgograd residents with intact parodontium and with mild periodontitis // Living and biosidic systems. 2013. No. 4. URL: http://www.jbks.ru/archive/issue-4/article-7 (date of access: 03.08.2018).
8. Uspenskya O.A., Shevchenko E.A., Boltenko S.A. Modern methods of treatment of chronic recurrent aphthous stomatitis in women with urogenital infection and without it // Modern problems of science and education. 2015. URL: http:// science-education.ru/ru/article/view?id=17642 (date of access: 03.08.2018).
9. Tsybikov N.N., Pinelis Yu.I., Malezhik M.S., Malezhik L.P. Detection of immunoglobulins, antibodies against heat shock proteins and IL-8 cytokine in the saliva of patients with chronic periodontal diseases // Medical immunology. 2010. Vol. 12, No. 4–5. P. 421–424.
10. Shmidt D.V., Shmagel K.V., Mozgovaya L.A., Belyaeva O.V. State of local immunity in patients with chronic generalized periodontitis // Stomatology. 2008. No. 4. P. 33–38.
11.Yarova S.P., Sanoyan V.V., Belous A.Yu., Sklyarenko D.E. The study of immunological parameters of blood serum of patients with generalized periodontitis against the background of type II diabetes mellitus // Bulletin of the problems of biology and medicine. 2009. No. 4. P. 177–180.
12. Gonzales J.R., Mann M., Stelzig J. [et al.]. Single-nucleotide polymorphisms in the IL-4 and IL-13 promoter region in aggressive periodontitis // J. Clin. Peridontol. 2007. Vol. 34. P. 473–479.
13. Gonzales J. R., Gröger S., Haley G. [et al.]. Production of interleukin- 13 is influenced by the interleukin-4 −34TT and −590TT genotype in patients with aggressive periodontitis // Scandinavian Journal of Immunology. 2011. Vol. 73, No. 2. P. 128–134.
14. Mattes J., Yang M., Siqueira A. [et al.]. IL-13 induces airways hyperreactivity independently of IL-4Ra chain in the allergic lung // J. Immunol. 2001. Vol. 167. P. 1683–1692.
15. Wilson T.G., Kornman K. Fundamentals or periodontics. Tokyo: Quintes-sence Publishing Co., 2006. 564 p.

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.