Home

The use of interferon and its inductors in outpatient pediatric practice

Written by Surovenko T.N., Priseko L.G.

  UDK: 616–022.6–053.2–085.33 | Pages: 79–83 | Full text PDF | Open PDF 

Annotation:

Objective. Interferon and its inductors are extensively used in pediatrics in combined treatment of acute upper respiratory tract viral infection due to their antiviral and immunomodulatory effect. Among national scientists and clinicians there is still no consensus on their effectiveness. The concrete problem is of interest.
Methods. We conducted a retrospective analysis of 344 case records of children who treated in 2012–2017 in Outpatient Clinic No. 3 (Vladivostok). The selection was made by the prescription of interferon and its inductors.
Results. Recombinant alpha-interferon (‘Veferon’), inductor ‘Anaferon detskiy’, and combined drug ‘Citovir-3’ were predominantly used in the group of young children. ‘Anaferon detskiy’ and ‘Citovir-3’ were predominantly used in the group of preteen children. Interferon inductors (‘Cikloferon’ and ‘Ergoferon’) were predominantly used in the third age group. Interferon inductors were also prescribed to children as a medical prevention before and after the immunization during 3–5 days. There was no report on allergic and autoimmune reactions to these drugs during the analysis of outpatient case records. In general, interferon drugs were prescribed in 43.3 %, and interferon inductors – in 56.7 % of cases. Conclusion. Thus interferon drugs and it inductors are extensively used in pediatrics in children from young age in combined therapy of acute upper respiratory tract viral infection, and as immunomodulators for preventive purposes as well. Recombinant interferon drugs and interferon inductors are registered in Russia and some counties of CIS, and its use in pediatrics requires a further analysis both the effectiveness and the safety.

Links to authors:

T.N. Surovenko, L.G. Priseko
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690002 Russian Federation)


1. The order of the Ministry of health of the Russian Federation of November 9, 2012 No. 798 n “About the approval of the standard of specialized medical care to children at acute respiratory diseases of moderate severity”.
2. Health in Russia 2017: Statistical compilation. Moscow: Rosstat, 2017. 170 p.
3. Baranaeva E.A. Acute respiratory viral infections in children: clinical features, current potential of prevention and treatment // International Review: Clinical Practice and Health. 2016. No. 2. P. 6–15.
4. Baranov A.А., Namazova-Baranova L.S., Lobzin Yu.V. [et al.]. Acute respiratory viral infection in children: modern approaches to diagnosis and treatment // Current Pediatrics. 2017. Vol. 14, No. 2. P. 100–108.
5. Vasilevskiy I.V. Clinical and pharmacological strategy for the use of Interferon inducers in pediatric practice // Pediatrics. Eastern Europe. 2015. No. 1. P. 88–100.
6. Dolinina L.Y. The advantages of using Ergoferon and Anaferon in the prevention and treatment of acute respiratory viral infections and influenza // Archive of Internal Medicine. 2015. No. 1. P. 38–40.
7. Dumova S. V. Possibilities of the use of Cycloferon in pediatrics // Practice of a Pediatrician. 2017. No. 4. P. 3–6.
8. Ershov F.I., Narovlyanskiy A.N. Usage of Interferon inducers during viral infections // Problems of Virology. 2015. No. 2. P. 5–10.
9. Zaplatnikov A.L., Burtseva E.I., Girina A.A. [et al.]. Modern possibilities and principles of rational treatment of influenza and other acute respiratory viral infections in children // Current Pediatrics. 2014. Vol. 13, No. 1. P. 129–133.
10. Kirilina S.A. Standards of diagnosis and treatment of influenza and acute respiratory viral infections. Cycloferon – experience of clinical use // Practice of a pediatrician. 2018. No. 1. P. 24–29.
11. Lozinskiy E.U., Eliseeva E.V., Shmykova I.I., Galanova Yu.D. Features of clinical pharmacology in children // Pacific Medical Journal. 2005. No. 3. P. 14–18.
12. Novikova I.A. The modern aspects of clinical application of immunomodulators // Medical News. 2015. No. 5. P. 23–26.
13. Chebotareva T.A., Zaplatnikov A.L., Zakharova I.N. [et al.]. Modern opportunities of Interferon therapy at influenza and acute respiratory viral infections // Children’s Infections. 2013. No. 2. P. 35–38.
14. Shamsheva O.V., Novosad E.V. Anaferon – the drug of choice in pediatric practice // Children’s infections. 2013. No. 3. P. 24–29.
15. World Health Organization. Cough and cold remedies for the treatment of acute respiratory infections in young children 2001. 39 p. URL: http://apps.who.int/iris/bitstream/handle/ 10665/66856/WHO_FCH_CAH_01.02.pdf?sequence=1 (date of access: 26.03.2018).

PUBLISHER: "MEDITSYNA DV"

Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.