Serological monitoring by evaluation of the effectiveness of vaccine prophylaxis of pneumococcal infection in organized groups of children

Written by Kolesnik D.S., Goncharov A.E., Kolodzhieva V.V., Nilova L.Yu., Netchaev V.V., Orishak E.A.

  UDK: 616.98:579.862.1–084:614.47]–078–036.22 | Pages: 89–90 | Full text PDF | Open PDF 


Objective. The study objective is to establish the epidemiological features of Streptococcus pneumoniae carrier of different serotypes in organized children groups during vaccinal prevention.
Methods. 1574 children were examined on the nasal S. pneumoniae carriage aged 2–7 y.o., having gone to preschool institutions of St. Petersburg.
Results. The percentage of S. Pneumoniae serotype strains covered by the action of 13-valent vaccine, was 36.03 %, that is lower than corresponding value (65.4 %), determined in a similar design study in St. Petersburg in 2010–2013. At the same time, it remained unclear whether this reduction could be considered the result of vaccine prevention, since the level of coverage with preventive vaccinations in the studied population was then quite low.
Conclusions. The wide spread of pneumococcal serotypes, unreached by the action of the 13-valent pneumococcal vaccine, on the one hand, indicates the need for constant monitoring of the pathogen population during mass immunization programs, and on the other hand, it makes it possible to raise the question of the need to expand the antigenic repertoire of the vaccines used.

Links to authors:

D.S. Kolesnik1, A.E. Goncharov1, 2, V.V. Kolodzhieva1, L.Yu. Nilova1, V.V. Netchaev1, E.A. Orishak1
1 North-West State Medical University named after I.I. Mechnikov (41 Kirochnaya St. Saint-Petersburg 191015 Russian Federation),
2 Institute of Experimental Medicine (12 Academician Pavlov St. 197376 Saint-Petersburg Russian Federation)

1. Briko N.I., Lobzin Yu.V., Baranov A.A. [et al.]. Evaluation of the effectiveness of vaccination:the main approaches and issues // Pediatric pharmacology. 2014. Vol. 11, No. 4. P. 8–15.
2. Lobzin Yu.V, Sidorenko S.V., Kharit S.M. [et al.]. Serotypes of Streptococcus pneumoniae causing major pneumococcal infections // Journal Infectology. 2013. T. 5, No. 4. P. 36–42.
3. Perova A.L., Rudakova A.V., Harit S.M. Efficacy of conjugate vaccines in pneumococcal infection prevention // Journal Infectology. 2014. T. 6, No. 2. P. 43–47
4. Fedoseenko M.V., Novikova D.A., Tkachenko N.E. [et al.]. Experience of application and safety assessment of the 13-valent pneumococcal conjugate vaccine in under-5 children // Pediatric pharmacology. 2014. Vol. 11, No. 5. P. 59–64.
5. Daniels C.C., Rogers P.D., Shelton C.M. A review of pneumococcal vaccines: Current polysaccharide vaccine recommendations and future protein antigens // J. Pediatr. Pharmacol. Ther. 2016. Vol. 21, No. 1. P. 27–35.
6. Hausdorff WP, Siber G., Paradiso P.R. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children // Lancet. 2001. Vol. 357, No. 9260. P. 950–951.
7. Nukka A., Ahman H., Yaich M. [et al.]. Serum and salivary antiantibodies in infants and children immunized with heptavalent pneumococcal conjugate vaccine // Pediatric Infectious Diseases Journal. 2001. Vol. 20. P. 25–33.
8. Pimenta F.C., Gertz Jr. R.E., Roundtree A. [et al.]. Rarely occurring 19A-like cps locus from a serotype 19F pneumococcal isolate indicates continued need of serology-based quality control for PCR-based serotype determinations // J. Clin. Microbiol. 2009. Vol. 47, No. 7. P. 2353–2354.
9. Wang X., Theodore M.J., Mair R. [et al.]. Clinical validation of multiplex real-time PCR assays for detection of bacterial meningitis pathogens // J. Clin. Microbiol. 2012. Vol. 50, No. 3. P. 702–708.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.