The role of derangements in hyaline cartilage remodeling in pathogenesis of the early stages of knee osteoarthrosis

Written by Gladkova E.V., Romakina N.A., Babushkina I.V., Belova S.V., Persova E.A.

  UDK: 616.72–007.248:616.71–018.3–003.973 | DOI: 10.17238/PmJ1609-1175.2019.1.46–49  Pages: 46–49 | Full text PDF | Open PDF 


Objective: The objective is to study the role of hyaline cartilage remodeling disorders in the early stages of osteoarthrosis.
Methods: We examined 73 female patients with early knee osteoarthrosis symptoms and 20 healthy women (average age 52 y.o). All patients were examined with magnetic resonance imaging, sonography for knee joints; blood serum levels were determined for interleukin-1β, neopterin, highly sensitive C-reactive protein, osteocalcin, CrossLaps, pyridinoline, oligomeric cartilage matrix protein (Human Cartilage Oligomaric Matrix Protein – COMP) and cartilage glycoprotein YKL-40.
Results: We noted an increase of interleukin-1β level at normal values of C-reactive protein and neopretin in blood serum. Markers of remodeling of cartilage and bone tissue (osteocalcin, Cross- Laps, pyridinoline, COMP and cartilage glycoprotein YKL‑40) showed a significant increase of concentration compared with control values.
Conclusions: Cytokine imbalance with pronounced hyperproduction of interleukin-1β plays a leading role in the pathogenesis of the early stages of primary osteoarthritis of the knee joints. Degenerative and dystrophic and inflammatory processes affecting the subchondral bone, synovium, hyaline cartilage, medial menisci, and also separate components of capsular ligamentous apparatus these joints develop against the remodeling disorders of bone and cartilage tissues.

Links to authors:

E.V. Gladkova, N.A. Romakina, I.V. Babushkina, S.V. Belova, E.A. Persova
Scientific Research Institute of Traumatology, Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky (148 Chernyshevskogo St. Saratov 410002 Russian Federation)

1. Aleksandrova E.N., Novikov A.A., Nasonov E.L. The role of biomarkers in diagnostics and forecasting of effectiveness of modern therapy of rheumatoid arthritis // Russian Clinical Laboratory Diagnostics. 2013. No. 8. P. 3–13.
2. Badokin V.V. The value of inflammation in osteoarthrosis progression // Consilium medicum. 2009. Vol. 11, No. 9. P.91–95.
3. Gladkova E.V., Karyakina E.V., Mamonova I.A. [et al.]. Bone tissue immune reactivity in patients with osteoarthrosis // Medical Immunology (Russia). 2015. Vol. 17, No. S. P. 329.
4. Kabalyk M.A. Biomarkers of subchondral bone remodeling in osteoarthritis // Pacific Medical Journal. 2017. No. 1. P. 36–41.
5. Kavalersky G., Smetanin S., Lychagin A., Moisov A. Risk factors for knee osteoarthritis // The Doctor. 2017. No. 3. P. 22–24.
6. Karyakina E.V., Norkin I.A., Gladkova E.V. [et al.]. Structural and functional characteristics of bone tissue and blood cytokines in health and disease of the joints // Russian Journal of Physiology. 2014. Vol. 100, No. 2. P. 238–247.
7. Кундер Е.В., Тябут Т.Д., Буглова А.Е. Ацеклофенак при остеоартрозе: эффективность, безопасность, хондропротекция // Международные обзоры: клиническая практика и здоровье. 2014. Т. 12, № 6. С. 34–43. Kunder E.V., Tyabut T.D., Buglova A.E. Aceclofenac in osteoarthritis: efficiency, safety and chondroprotection // International Reviews: Clinical Practice and Health. 2014. Vol. 12, No. 6. P. 34–43.
8. Пилипович А.А. Остеоартроз: патогенетические и терапевтические аспекты // Русский медицинский журнал. 2016. № 7. С. 464–468. Pilipovich A.A. Osteoarthrosis: pathogenetic and therapeutic aspects // Russian Medical Journal. 2016. No. 7. P. 464–468.


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