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Low molecular weight heparin enixum in the prevention and treatment of thrombosis in oncology clinic

Written by Somonova O.V., Elizarova A.L., Blindar V.N., Dobrovolskaya M.B., Nesterova Yu.A.

  UDK: 616–006.04–06:616–005.6–085.273 | DOI: 10.17238/PmJ1609-1175.2019.1.56–60  Pages: 56–60 | Full text PDF | Open PDF 

Annotation:

Objective: Oncological patients are at high risk of thrombotic complications, which worsen the outcomes of antitumor treatment and occupy one of the leading places among the causes of death. The aim of this study was to evaluate the efficacy and safety of the use of anticoagulant direct action of domestic production of Enixum (enoxaparin sodium) for the prevention and treatment of thrombosis in cancer patients.
Methods: The system of hemostasis and the frequency of thrombotic complications in 210 oncological and gynecological patients undergoing surgical treatment were studied. 80 people (group 1) received Enixum for 7–15 days of the postoperative period. Group 2 (130 people) – patients who did not receive medication prophylaxis of thrombotic complications (control group). Also, 30 oncological patients with acute thrombosis and pulmonary embolism, were studied.
Results: The use of low molecular weight heparin Enixum in the postoperative period and in patients with acute thrombosis and pulmonary embolism significantly reduces the intensity of intravascular coagulation, the frequency of venous thrombosis and prevents fatal thromboembolism, which expands the possibilities of anticancer treatment and improves the quality of life of cancer patients.
Conclusions: Enixum is an effective and safe drug for the prevention and treatment of thrombosis in oncology clinic.

Links to authors:

O.V. Somonova, A.L. Elizarova, V.N. Blindar, M.B. Dobrovolskaya, Yu.A. Nesterova
National Medical Research Center of Oncology named after N.N. Blokhin (24 Kashirskoe HW Moscow 115478 Russian Federation)


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