Primary malignant neoplasms of cerebrospinal nervous system in children: perspectives of improvement of diagnostic and treatment approaches

Written by Volkova A.R., Vahitov Kh.M., Kumirova E.V., Shammasov R.Z., Nizamutdinova E.I., Osipova I.V., Grishina E.N., Karimova L.R.

  UDK: 616.831/832–006.6–07/08–053.2 | DOI: 10.17238/PmJ1609-1175.2019.2.8–10 | Pages: 8–10 | Full text PDF | Open PDF 


The article presents review of publications of cerebrospinal nervous system (CNS) tumors in children, their diagnostics, classification and therapy. Malignant neoplasms of CNS in children of different age are represented by a wide range of histomolecular groups. In the classification invented by WHO in 2016, for the first time, the basis for their separation was laid not only the histological structure, but also the most significant molecular genetic features or chromosomal aberrations. These features broaden the possibilities of target therapy, enable to minimize toxic effects and correct timing as well as to improve programmed treatment and to increase survival index.

Links to authors:
A.R. Volkova1, Kh.M. Vahitov1, E.V. Kumirova2, 3, R.Z. Shammasov3, E.I. Nizamutdinova4, I.V. Osipova4, E.N. Grishina4, L.R. Karimova4
1 Kazan State Medical University (49 Butlorov St. Kazan 420012 Russian Federation),
2 Pirogov Russian National Research Medical University (Ostrovitianov St. Moscow 117997 Russian Federation),
3 Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (1 SamoryMashela St. Moscow 117997 Russian Federation),
4 Republican Children›s Clinical Hospital Ministry of Health of Tatarstan (140 Orenbursky Path, Kazan 420059 Russian Federation)

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