Risk factors for retinopathy of prematurity at different stages of gestation

Written by Krasnogorskaya V.N., Gusev A.N., Syromukova A.S.

  UDK: 616.735–007.281:617.723–053.32 | DOI: 10.17238/PmJ1609-1175.2019.2.11–14 | Pages: 11–14 | Full text PDF | Open PDF 


Objective: Study objective is to determine the prevalence of retinopathy of prematurity that required a neonatal resuscitation, and is to assess the impact of some risk factors with the use of modern perinatal technologies of breathing support and further developmental care in Amur Region.
Methods: We examined two matched infants groups with a gestational age at birth 34 weeks and/or body weight 2,250 gr or less: 102 infants with retinopathy of prematurity (1st group) and 125 infants without retinopathy of prematurity (2nd group).
Results: Depending on the gestational age the prevalence of retinopathy of prematurity distributed as follows: among infants born until the 28th week of pregnancy – 77.4 %, until the 30th week – 48.5 %, until 32nd week – 31.2 %. Depending on body weight at birth the prevalence of retinopathy of prematurity was: less than 1,000 gr – 55.8 %, less than 1,250 gr – 52.7 %, less than 1,500 gr – 40.3 %, less than 1,750 gr – 30.9 %, less than 2,000 gr – 24.1 %.
Conclusions: The prevalence of retinopathy of prematurity is 17.8 % of the total number of infants born until the 34 weeks of gestational age and body weight at birth less than 2,000 gr in Amur Region. Birth asphyxia can be considered to be the most significant intranatal risk factor for retinopathy of prematurity. Reduction of the first rate according to Apgar scale up to 4 scores and less in infants with very low and extremely low body weight does not only increase the frequency of development of severe perinatal injury of the central nervous system but also is associated with retinopathy of prematurity.

Links to authors:

V.N. Krasnogorskaya, A.N. Gusev, A.S. Syromukova
Amur State Medical Academy (95 Gorkogo St. Blagoveschensk 675013 Russian Federation)

1. Astasheva I.B., Kan I.G., Aksenova I.I. [et al.]. The role of blood transfusions in the development and course of retinopathy of prematurity // Russian Pediatric Ophthalmology. 2010. No. 3. P. 13–15.
2. Saidasheva E.I., Fomina N.V. Retinopathy of prematurity in children with ENMT in St. Petersburg // Retinopathy of Prematurity 2011: materials all-Russian Scientific Conf. Moscow, 2011. P. 12–14.
3. Sidorenko E.I, Astasheva I.B, Aksenova I.I. [et al.]. Analysis of the frequency of retinopathy of prematurity in perinatal centers of Moscow // Russian Pediatric Ophthalmology. 2009. No. 4. Р. 8–11.
4. Sidorenko E.I., Nikolaeva G.V. Biochemical autoregulation of the eye vessels as a risk factor for the development of retinopathy of prematurity // Russian Pediatric Ophthalmology. 2007. No. 4. P. 7–9.
5. Katargina L.A., Kogoleva L.V. Recommendations for the organization of early detection and prophylactic treatment of active retinopathy of prematurity // Russian Ophthalmological Journal. 2008. No. 3. P. 43–47.
6. Fedorov A.A. Prenatal development of the vessels of the reticular membrane of the human eye // Vestnik Oftalmologii. 2003. No. 4. P. 59–63.
7. Alon T. Hemo I., Itin A. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity // Nat. Med. 1995. Vol. 1. P. 1024–1028.
8. Apelin is a potent activator of tumour neoangiogenesis / ed. S.C. Sorli // Oncogene. 2007. Vol. 26. Р. 7692¬–7699.
9. Ashton N. Oxygen and the growth and development of retinal vessels. In vivo and in vitro studies. The XX Francis I. Proctor Lecture // Am. J. Ophthalmol. 1966. Vol. 62, No. 3. P. 412–435.
10. Ashton N., Ward B., Serpell G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia // Br. J. Ophthalmol. 1954. Vol. 38. P. 397–432.
11. Association of maternal age to development and progression of retinopathy of prematurity in infants of gestation age under 33 weeks / ed. A. Uchida // J. Ophthalmol. 2014. P. 187929.
12. Carlini R.G., Reyes A., Rothstein M. Recombinant human erythropoietin stimulates angiogenesis in vitro // Kidney Int. 1995. Vol. 47, No. 3. P. 740–745.
13. Chen J., Stahl A., Hellstorm A., Smith L.E. Current update on retinopathy of prematurity: screening and treatment // Curr. Opin. Pediatr. 2011. Vol. 23, No. 2. P. 173–178.


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