Regularities of macular blood flow in pregnant women with preeclampsia in the III trimester and after delivery, risk factors for development of vascular pathology of posterior segment of the eye

Written by Kolenko O.V., Sorokin E.L., Khodzhaev N.S., Pomytkina N.V., Chizhova G.V., Berdakov Yu.N., Fil A.A., Pashentsev Ya.E.

  UDK: 618.3–06:616.8–009.24–02:617.723 | DOI: 10.17238/PmJ1609-1175.2019.2.25–28 | Pages: 25–28 | Full text PDF | Open PDF 


Objective: clinical assessment of macular blood flow in pregnancy complicated by preeclampsia.
Methods: 102 women aged from 19 to 55 y.o. participated in the study. The main group – 46 pregnant women with preeclampsia; the 1st experimental group – 20 women with physiological gestation course; the 2nd experimental group – 16 non-pregnant women with occlusions of the branches of the central retinal vein; the control group – 20 healthy women. We studied macular blood flow and the level of endothelin-1 in lacrimal fluid with optical coherence tomography method. The study was conducted on the 35–36th week of pregnancy and in 6–9 months after delivery.
Results: We determined the correlation between endothelial dysfunction progression (as evidenced by high levels of endothelin- 1 in the lacrimal fluid) and development of vascular pathology of posterior segment of the eye.
Conclusions: High risk factors for the development of vascular pathology of posterior segment of the eye in the after-delivery period: decrease of the total average vascular density in the superficial plexus by 20 % or more in the III trimester of gestation, decrease of subfoveal thickness of the choroid by 15 % or more, absence of positive dynamics of optical coherence tomography values in 6–9 months after delivery.

Links to authors:
O.V. Kolenko1, 2, E.L. Sorokin1, N.S. Khodzhaev3, N.V. Pomytkina1, G.V. Chizhova2, Yu.N. Berdakov⁴, A.A. Fil1, Ya.E. Pashentsev1
1 Khabarovsk branch of S.N. Fyodorov NMRC “MNTK “Eye Microsurgery” (211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation),
2 Postgraduate Institute for Public Health Workers (9 Krasnodarskaya St. Khabarovsk 680000 Russian Federation),
3 S.N. Fyodorov NMRC “MNTK “Eye Microsurgery” (59a Beskudnikovskii blvd. Moscow 127486 Russian Federation),
4 Perinatal Center (85, Istomina St. Khabarovsk 680028 Russian Federation)

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