Prospects of complex use of pharmacological neuroprotection and vascular endothelial growth factor inhibitors in patients with macular edema with retinal vein occlusion

Written by Danilova L.P., Egorov V.V., Smoliakova G.P., Povalyaeva D.A., Zhaivoronok N.S., Emanova L.P.

  UDK: 617.736–005.98–02:616.145.154–085.214.2 | DOI: 10.17238/PmJ1609-1175.2019.2.33–37 | Pages: 33–37 | Full text PDF | Open PDF 


Objective: to assess clinical effectiveness of complex use of ‘Lucentis’ and ‘Meldonium’ in the treatment of macular edema caused by retinal vein occlusion.
Methods: 35 patients (35 eyes) with macular edema with retinal vein occlusion were undergone three consecutive “load” intravitreal administrations of 0.5 mg (0.005 mL) of ‘Lucentis’ once a month. In 19 cases, the introduction of Lucentis was supplemented with daily parabulbar injections of 0.5 ml of Meldonium solution for 10 days.
Results: Using Meldonium visual acuity increased by 3.5 times, light sensitivity of the central zone of the retina – 2.1 times and electrical lability – 1.2 times. Visual electric threshold of retina decreased by 1.5 times.
Conclusions: The improvement of functional parameters in the combined treatment is due to the ability of Meldonium to activate the recovery of the chorioretinal microblood in the macula. The results of a clinical study on the reversibility of ischemic and metabolic injuries of the neuroreceptors of the macula in patients with macular edema with retinal vein occlusion allow us to recommend ‘Meldonium’ for the improvement of visual functions after the intravitreal administration of ‘Lucentis’.

Links to authors:

L.P. Danilova1, 2, V.V. Egorov1, 2, G.P. Smoliakova1, 2, D.A. Povalyaeva1, N.S. Zhaivoronok1, L.P. Emanova1
1 Khabarovsk branch of S.N. Fyodorov NMRC “MNTK “Eye Microsurgery” (211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation),
2 Postgraduate Institute for Public Health Workers (9 Krasnodarskaya St. Khabarovsk 680000 Russian Federation)

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