Granichnaya N.V., Zaytseva E.A., Perelomova O.V.

Written by Granichnaya N.V., Zaytseva E.A., Perelomova O.V.

  UDK: 579.861.2:616.12–089.168.1–06:616.94–022.7–085.33 | DOI: 10.17238/PmJ1609-1175.2019.2.28–42 | Pages:8–42 | Full text PDF | Open PDF 


Objective: is to assess the resistance to antibiotics and determine phenotypes of resistance of clinical isolates of coagulase negative staphylococci (CNS) recovered from patients of cardiac surgery hospital.
Methods: We analyzed antibiograms of 152 isolates of CNS recovered from postoperative wound, from cusps and artificial cardiac pacemaker incisions, from tracheobronchial tree washouts, blood, pleural fluid, urine, and from nasal discharge of cardiac patients. Recovering, identification and determination of culture sensibility to antibiotic medications were conducted with microbiological analyzer Vitek 2 Compact (bioMerieux).
Results: CNS were recovered more often from biological material among which Staphylococcus epidermidis prevailed. Analysis of antibiotic resistance showed the spread of methicillin resistance. A large number of resistant staphylococci were detected from the tracheobronchial tree washouts, and less from surgical wounds. Staphylococcus warneri, isolated from the blood, was resistant to all classes of antibiotics, with the exception of the reserve group medication, tigecycline.
Conclusions: The predominant microorganisms among those isolated from patients at the cardiac surgical hospital were CNS, more often S. epidermidis. The spread of methicillin resistance in staphylococci tends to increase. The high activity of tigecycline, daptomycin, vancomycin and linezolid with respect to CNS has been established, which must be considered when planning antibiotic therapy.

Links to authors:

N.V. Granichnaya, E.A. Zaytseva, O.V. Perelomova
Pacific State Medical University (2 Ostryakova Ave. Vladivostok 690002 Russian Federation)

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