Impact of hirudotherapy and gestagens on angiogenic growth factors and uterine hemodynamics in women with primary oligomenorrhea in past medical history

Written by Stokoz K.Yu., Lysyak D.S., Bystritskaya T.S.

  UDK: 618.177–02:618.175–085.811.2:615.256.52 | DOI: 10.17238/PmJ1609-1175.2019.2.65–68 | Pages: 65–68 | Full text PDF | Open PDF 


Objective: to assess the impacto of hirudotherapy and gestagens on angiogenic growth factors and uterine hemodynamics in women with primary oligomenorrhea in past medical history.
Methods: We examined 80 women with primary oligomenorrhea in past medical history (the main group) and 40 women with regular menstrual cycle (the control group). 40 women of the main group received hirudotherapy (the 1st subgroup), and 40 women took gestagens (the 2nd subgroup). We studied concentration of vascular-endothelial growth factor А (VEGF-А) and its soluble receptors (sVEGFR1) in blood serum. We run ultrasound examination with Doppler-metry of uterine arteries.
Results: Anovular menstrual cycle was detected in 17 patients; lack of luteal phase of menstrual cycle was detected in 63 patients. The initial concentration of VEGF-A was 2.2 times less, and resistance index of uterine arteries were higher than in the control group. After periconceptional multivitamin supplementation the concentration of VEGF-А and sVEGFR1 increased in blood serum, and resistance index decreased. The concentration of angiogenic growth factors after hirudotherapy was significantly higher than after therapy with gestagens. We determined a strong inverse correlation between concentration of angiogenic factors and resistance index value of uterine arteries.
Conclusions: Decrease of resistance index and hemodynamics improvement in uterine arteries after hirudotherapy is explained by increased angiogenesis, and after intake of gestagens – by decrease of vascular resistance.

Links to authors:

K.Yu. Stokoz, D.S. Lysyak, T.S. Bystritskaya
Amur State Medical Academy (95 Gorkogo St. Blagoveshchensk 675006 Russian Federation)

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