Optimization techniques to treat injuries of different genesis

Written by Olifirova O.S., Kozka A.A.

  UDK: 616–001–085.33/835.3 | DOI: 10.17238/PmJ1609-1175.2019.2.80–83 | Pages: 80–83 | Full text PDF | Open PDF 


Objective: to assess results of treatment of injuries of different genesis with the use of antioxidants and hyperbaric oxygen therapy (HOT).
Methods: We analyzed the results of treatment of 80 patients aged 20–60 y.o. with injuries of different genesis and localization divided into main and control groups (40 patients each). Along with traditional treatment the main group received antioxidant therapy (oral intake of biologically active supplement “Lavitol-V” and applied topically – dihydroquercetin powder for 21 days). Simultaneously patients with burns of the1-2 stages received 8–10 sessions of HOT, and patients with burns of the 3 stage and with persistent wounds received 3–4 sessions of HOT with consecutive autodermoplasty and continued to receive HOT with antioxidant therapy since the first day of post-surgery period.
Results: Positive wound process was observed in patients of the main group: less pain severity, early epithelization and wounds cicatrization, decrease of proinflammatory cytokines level and lipid peroxidation rate in blood serum. Due to activation of repair process we were able to reduce the time of self-epithelization in burns of the 1–2 stages, and the time of preoperative preparation for deferred autodermoplasty in burns of the 3 stage and in persistent wounds, and to improve the results of graft retention compared to a traditional treatment.
Conclusions: Antioxidant therapy and HOT influence pathogenetically on wound process, and suggested way of treatment combines positive effects of both methods.

Links to authors:

O.S. Olifirova, A.A. Kozka
Amur State Medical Academy (95 Gorkogo St. Blagoveschensk 675000 Russian Federation)

1. Akhmedov B.A. Mexidol in the complex treatment of gunshot wounds of soft tissues, gunshot fractures and their infectious complications: Thesis MD. Moscow, 2004. 28 p.
2. Bagaev V.G., Sergeev V.V., Bobrova A.A. [et al.]. Hyperbaric oxygen therapy in the treatment of wounds in children // Wounds and Wound Infections. 2014. Vol. 2, No. 1. P. 31–37.
3. Klebanov G.I., Lyubitsky O.B., Ilyina S.E. [et al.]. Antioxidant activity of inhibitors of free radical reactions used in dressing to treat wounds // Biomedicine Chemistry. 2006. Vol. 52, No. 1. P. 69–82.
4. Kozka A.A., Olifirova O.S. Antioxidants and hyperbaric oxygenation in complex treatment of patients with deep burns // Practical Medicine. 2015. No. 6. P. 112–115.
5. Nomokonov, E.V. Lazutkin M.N., Miromanov L.M. Antioxidant stimulation of reparative processes in the wound in the experiment // Bulletin of ESSC SB RAMS. 2012. No. 4, Part 1. P. 215–217.
6. Naumov A.A., Potselueva M.M. Beneficial effect of the liposomal form of dihydroquercetin on the process of skin regeneration after thermal burn // Cytology. 2010. Vol. 52, No. 4. P. 311–316.
7. Okovity S.V. Clinical pharmacology of antihypoxants and antioxidants. St. Petersburg: PHARMindex, 2005. 72 р.
8. Olifirova O.S., Bregadze A.A., Kozka A.A., Kiridon O.I. A method of stimulating the healing of dermal burns: The Patent of Russia No. 2577950, 2016. Bull. № 17.
9. Olifirova O.S., Bregadze A.A., Kozka A.A., Kiridon O.I. А method of optimizing the treatment of deep burns: The Patent of Russia No. 2587638. Bull. № 8.
10. Flavonoids: biochemistry, biophysics, medicine / Tarakhovsky Yu.S., Kim Yu.A., Abdrasilov B.S, Muzafarov E.N.; ex. ed. E.I. Maevsky. Pushchino: Sunchrobook, 2013. 310 p.
11. Kharaeva Z.F., Mustafaev M.Sh., Rehviashvili B.A. et al. Cytokine profile of blood and wounds of patients with odontogenic phlegmon // Cytokines and Inflammation. 2007. No. 4. URL: http:// www.cytokines.ru/2007/4/Art6.php (date of access: 11.06.2018).
12. Khlybov V.S. Clinico-laboratory substantiation of the use of the antioxidant mexidol in the complex treatment of the furuncle of the face: Thesis MD. Volgograd, 2012. 24 p.
13. Adly A.A.M. Oxidative stress and disease: an updated review // J. Immunol. 2010. No. 3. Р. 129–145.
14. Kotsovos A. The use of hyperbaric oxygen therapy for wound healing in people with diabetes // Journal of Diabetes Nursing. 2012. Vol. 16, No. 6. Р. 227–232.
15. Ryssel H., Germann G., Kloeters O. [et al.]. Dermal substitution with Matriderm in burns on the dorsum of the hand // Burns. 2010. Vol. 36, No. 8. P. 1248–1253.


Founded in 1997  |  Editions in a year: 4, Articles in one issue: 30 |  ISSN of print version: 1609-1175  |  Ind.: 18410 (Agency "Rospechat’")  |  Edition: 1000 c.