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Значение сероводорода в регуляции функций органов

22 Июль 2012
Автор: Вараксин А.А., Пущина Е.В.

  Индекс УДК: 546.221.1:612.822:616 | Страницы: 27–34 | Полный текстСкачать PDF 

Аннотация:

В обзоре рассматриваются новые данные литературы и результаты собственных исследований по физиологии и патологии газотрансмиттера сероводорода. Сероводород синтезируется из цистеина c помощью пиридоксаль‑5’‑фосфат‑зависимых ферментов цистатионин‑β‑синтазы или цистатионин‑γ‑лиазы. Он стимулирует АТФ‑зависимые калиевые каналы в гладкомышечных клетках сосудов, нейронах, кардиомиоцитах и β‑клетках поджелудочной железы, участвуя в регуляции сосудистого тонуса, сокращении кардиомиоцитов, нейротрансмиссии и секреции инсулина. Рассматривается влияние сероводородпродуцирующих систем в патогенезе артериальной и легочной гипертензии, болезни Альцгеймера, циррозе печени.

Ссылки на авторов:

А.А. Вараксин
Вараксин Анатолий Алексеевич – д‑р биол. наук, ведущий научный сотрудник лаборатории цитофизиологии ИБМ ДВО РАН; e‑mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.
Е.В. Пущина
Институт биологии моря им. А.В.Жирмунского ДВО РАН (690041 г. Владивосток, ул. Пальчевского, 17)

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