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Роль 15‑гидроксиэйкозатетраеновой кислоты в инактивации калиевых каналов и спазме внутренней сонной артерии при гипоксии

24 Июнь 2013 Автор: Янмей Жу, Ли Чен, Веньян Лиу, Вейжи Ванг, Далинг Жу, Юлан Жу

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Аннотация:

Summary – Severe hypoxia induces the constriction of internal carotid arteries (ICA), which worsens ischemic stroke in the brain. A few metabolites are presumably involved in hypoxic vasoconstriction, however, less is known about how such molecules provoke this vasoconstriction. We have investigated the influence of 15‑hydroxyeicosatetrienoic acid (15‑HETE) produced by 15‑lipoxygenase (15‑LOX) on vasoconstriction during hypoxia. As showed in our results, 15‑LOX level increases in ICA endothelia and smooth muscles. 15‑HETE enhances the tension of ICA ring in a dose‑dependent manner, as well as attenuates the activity and expression of voltage‑gated potassium (Kv) channels. Therefore, the down‑regulation of Kv channels by 15‑HETE during hypoxia weakens the repolarization of action potentials and causes a dominant influx of calcium to enhance smooth muscle tension and ICA constriction.

Ссылки на авторов:

Yulan Zhu
Department of Neurology. Tel.: 86‑451‑89778959, 86‑151‑34556239, Fax: 86‑451‑86605656, e‑mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.
Yanmei Zhu, Li Chen, Wenjuan Liu, Weizhi Wang, Yulan Zhu
Second Affiliated Hospital of Harbin Medical University
Daling Zhu
College of Pharmacy of Harbin Medical University (157 Baojian Road, Nangang District, Harbin 150081 P.R. China)

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ИЗДАТЕЛЬСТВО: Медицина ДВ

Год основания: 1997  |  Выпусков в год: 4, Статей в выпуске: 30  |  ISSN печатной версии: 1609-1175  |  Подписной  индекс: 18410 (Агентство “Роспечать”)  |  Тираж: 1000 экз.

 

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