Эффективность фотодинамической терапии и рекомбинантного человеческого эндостатина в угнетении роста перевиваемой глиомы U251 in vivo

24 Июнь 2013 Автор: Ху Шаошан, Жан Кви, Юе Ву

  Индекс УДК: 616‑006.484‑085277.3:615.831 | Страницы: 67-71 | Полный текст статьи. PDF файл | Открыть PDF 


Summary – Endostar, a novel recombinant human endostatin expressed in Escherіchіa coli, was approved by the State FDA in China. To investigate the effect of endostar and photodynamic therapy (PDT) on the in vivo growth of U251 glioma. Seven days
after inoculation with U251 cells, nude mice with MRI‑confirmed glioma were randomly assigned to 4 groups: PDT+endostar group; PDT group; endostar group and control group. In the PDT group, survival prolonged, accompanied by an increase in apoptosis, when compared with the control group. Furthermore, these changes were more pronounced in the PDT+endostar group. After PDT, hypoxia inducible factor‑1α (HIF‑1α) and vascular endothelial growth factor A (VEGF‑A) expression was markedly increased and after endostar treatment, HIF‑1α and VEGF‑A expression was significantly reduced. PDT, in combination with endostar, can significantly inhibit the growth of U251 glioma. This approach may represent a promising strategy in the treatment of malignant tumors.

Ссылки на авторов:

Shaoshan Hu
postdoctor, professor of Harbin Medical University; e‑mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.
Second Affiliated Hospita
Zhan Qi, Yue Wu
Fourth Affiliated Hospital of Harbin Medical University (157 Baojian Road, Nangang District, Harbin 150081 P.R. China)

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Год основания: 1997  |  Выпусков в год: 4, Статей в выпуске: 30  |  ISSN печатной версии: 1609-1175  |  Подписной  индекс: 18410 (Агентство “Роспечать”)  |  Тираж: 1000 экз.


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