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Углеводные биополимеры для адресной доставки белковых препаратов, нуклеиновых кислот и полисахаридов

Автор: Хотимченко Ю.С.

  Индекс УДК: 615.3.032:577.11/.12 | Страницы: 5-13 | Полный текст статьи. PDF файл | Открыть PDF 

Аннотация:

Статья посвящена новому научному направлению – разработке систем адресной доставки белков, нуклеиновых кислот и полисахаридов через тканевые барьеры. Внимание уделено природным нетоксичным соединениям, составляющим группу углеводных биополимеров. Описаны структура, физико‑химические свойства и фармакологическая активность пектинов, альгинатов, хитозанов, каррагинанов и фукоиданов и микро‑ и наносистем на основе этих соединений. Приведены примеры использования наночастиц хитозана для энтерального введения гормонов, генов эритропоэтина и гепарина. Подчеркнута необходимость проведения токсикологических исследований новых лекарственных форм.

Ссылки на авторов:

Ю.С. Хотимченко
Институт биологии моря им. А.В. Жирмунского ДВО РАН (690041, г. Владивосток, ул. Пальчевского, 17),
Школа биомедицины Дальневосточного федерального университета (690950, г. Владивосток, ул. Суханова, 8),
Тихоокеанский государственный медицинский университет (690950, г. Владивосток, пр‑т Острякова, 2)

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ИЗДАТЕЛЬСТВО: Медицина ДВ

Год основания: 1997  |  Выпусков в год: 4, Статей в выпуске: 30  |  ISSN печатной версии: 1609-1175  |  Подписной  индекс: 18410 (Агентство “Роспечать”)  |  Тираж: 1000 экз.

 

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