Home

Аваскулярный некроз головки бедренной кости

Автор: Мустафин Р.Н., Хуснутдинова Э.К.

  Индекс УДК: 616.718.41-002.4 | Страницы: 27–35 | Полный текст статьи. PDF файл | Скачать PDF 

Аннотация:

Аваскулярный некроз головки бедренной кости – мультифакториальное заболевание с прогрессирующим развитием тяжелого вторичного коксартроза. Различают вторичный и идиопатический остеонекроз. Патогенез болезни связан с местным нарушением кровообращения, коагулопатиями и ослаблением регенерации костной ткани. Гистологиче ски пораженная кость характеризуется образованием пустых лакун с васкуляризированной фиброзной тканью вокруг, в субхондральной зоне и зоне некроза возрастает активность остеокластов, в то время как в зоне склероза усиливается активность остеобластов. Среди лабораторных показателей определяется значительное повышение уровней ингиби тора-1 активатора плазминогена, фактора Виллебранда, ингибитора-1 активатора плазминогена, С-реактивного белка, интерлейкина-33, снижение уровней грелина, остеопротегерина, перекрестно-связанного N-концевого телопептида, С-концевого пептида проколлагена-1, фактора некроза опухоли-α, miR-17-5p. При генетических исследованиях выяв ляются мутации в гене COL2A1 и протромбина, ассоциации полиморфных локусов в генах фактора V Лейдена, метилен тетрагидрофолатредуктазы, тканеспецифического активатора плазминогена, ингибитора-1 активатора плазминогена. Лечение включает оперативные вмешательства и коррекцию цитоактивности. Имеются данные о способности бисфос фонатов предотвращать коллапс головки бедра.

Ссылки на авторов:

Р.Н. Мустафин1, Э.К. Хаснутдинова1, 2
1 Башкирский государственный университет (450076, г. Уфа, ул. Заки Валиди, 32),
2 Институт биохимии и генетики Уфимского научного центра РАН (450054, г. Уфа, пр-т Октября, 71)
Мустафин Рустам Наилевич – аспирант кафедры генетики и фундаментальной медицины БашГУ; e-mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.  


1. Aoyama T., Fujita Y., Madoba K. [et al.]. Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study // Arch. Phys. Med. Rehabil. 2014. pii: S0003-9993(14)01210-6.
2. Assouline-Dayan Y., Chang C., Greenspan A. [et al.]. Pathogenesis and natural history of osteonecrosis // Seminars in Arthritis and Rheumatism. 2002. Vol. 32. P. 94–124.
3. Babhulkar S. Osteonecrosis of femoral head: Treatment by core decompression and vascular pedicle grafting // Indian J. Orthop. 2009. Vol. 43, No. 1. P. 27–35.
4. Beckmann R., Shaheen H., Kweider N. [et al.]. Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head // The Scientific World Journal. 2014. ID 347813. http://dx.doi. org/10/1155/2014/347813.
5. Chang X., Luo Z., Li X. [et al.]. Meta-analysis of factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility // Biomedical reports. 2013. Vol. 1. P. 594–598.
6. Chen W., Liu Y., Lin M. [et al.]. Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13 // Am. J. Hum. Genet. 2004. Vol. 75. P. 310–317.
7. Chen Y., Zeng C., Zeng H. [et al.]. Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults // Exp. Ther. Med. 2015. Vol. 9, No. 1. P. 77–83.
8. Chotivichit A., Korwutthikulrangsri E., Pornrattanamaneewong C., Achawakulthep C. Core decompression with bone marrow injection for the treatment of femoral head osteonecrosis // J. Med. Assoc. Tai. 2014. Vol. 97. P. 139–143.
9. Gagala J., Buraczynska M., Mazurkiewicz T., Ksiazek A. Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland // BMC Musculoskeletal Disorders. 2013. Vol. 14. P. 264–271.
10. Garcia F.L., Junior E.L., Picado C.H. Coagulation disorders in patients with femoral head osteonecrosis // Acta Ortop. Bras. 2013. Vol. 21, No. 1. P. 43–45.
11. He T., Wu W., Huang Y. [et al.]. Multiple biomarkers analysis for the early detection of prosthetic aseptic loosening of hip arthroplasty. Int. Orthop. 2013; 37 (6): 1025-1031.
12. Houdek M., Wyles C., Martin J. Stem cell treatment for avascular necrosis of the femoral head: current perspectives // Stem Cells and Cloning: Advances and Applictions. 2014. Vol. 7. P. 65–70.
13. Jia J., Feng X., Xu W. [et al.]. MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in nontraumatic osteonecrosis // Experimental and Molecular Medicine. 2014. Vol. 46. P. e107. doi:10.1038/emm.2014.43.
14. Kannu P., O’Rielly D.D., Hyland J.C., Kokko L.A. Avascular necrosis of the femoral head due to a novel C propeptide mutation in COL2A1 // Am. J. Med. Genet. Part A. 2011. Vol. 155A, No. 7. P. 1759–1762.
15. Karasuyama K., Yamamoto T., Motomura G. [et al.]. Osteonecrosis of the femoral head with collapsed medial lesion // Clinical Medical Insights: Case Reports. 2014. Vol. 7. P. 103–106.
16. Kaushik A., Das A., Cui Q. Osteonecrosis of the femoral head: An update in year 2012 // World J. Orthop. 2012. Vol. 3, No. 5. P. 49–57.
17. Kerachian M.A., Cournoyer D., Harvey E. [et al.]. New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model // Arthritis Research and Therapy. 2010. Vol. 12. P. 124–136.
18. Komurcu E., Oktay M., Kaymaz B. [et al.]. Preventive effects of coenzyme Q10 (CoQ10) on steroid-induced osteonecrosis in rats // Acta Orthop. Traumatol. Turc. 2014. Vol. 48, No. 2. P. 217–222.
19. Leo M., Milena F., Ruggero C. Biophysical stimulation in osteonecrosis of the femoral head // Indian J. Orthop. 2009. Vol. 43, No.1. P. 17–21.
20. Li C., Shen L., Yang Y., Shuai B. [et al.]. Plasma ghrelin and von Willebrand factor levels in patients with non-traumatic osteonecrosis of the femoral head // Hip Int. 2014. doi: 10.5301/HIP.2014.12739.
21. Li X., Xu X., Wu W. Comparison of bone marrow mesenchymal stem cells and core decompression in treatment of osteonecrosis of the femoral head: a meta-analysis // Int. J. Clin. Exp. Pathol. 2014. Vol. 7, No. 8. P. 5024–5030.
22. Liu Y., Chen W., Lin Y. [et al.]. Type II collagen gene variants and inherited osteonecrosis of the femoral head // N. Engl. J. Med. 2005. Vol. 352. P. 2294–2301.
23. Liu Y., Liu S., Zhou S. A modified porous tantalum implant technology for osteonecrosis of the femoral head: survival and prognostic evaluations of onversion into total hip arthroplasty // Zhonghua Yi Xue Za Zhi. 2014. Vol. 94, No. 31. P. 2429–2433.
24. Luo R.B., Lin T., Zhong H.M. [et al.]. Evidence for using alendronate to treat adult avascular necrosis of the femoral head: a systematic review // Med. Sci. Monit. 2014. Vol. 20. P. 2439–2447.
25. Madhuri V., Dutt V., Samuel K., Gahukamble A. Intra-operative head vascularity assessment: An innovative and simple technique // Indian J. Orthop. 2011. Vol. 45, No. 3. P. 231–235.
26. Mao Q., Jin H., Liao F. [et al.]. The efficacy of targeted intraarterial delivery of concentrated autologus bone marrow containing mononuclear cells in the treatment of osteonecrosis of the femoral head: a five year follow-up study // Bone. 2013. Vol. 57, No. 2. P. 509–516.
27. Mazloumi S.M., Erbahimzadeh V.H., Kachooei A.R. Evolution in diagnosis and treatment of Legg-Calve-Perthes disease // Arch. Bone Joint Surg. 2014. Vol. 2, No. 2. P. 86–92.
28. Mishra P.K., Gupta A., Gaur S.C. Results of triple muscle (sartorius, tensor fascia latae and part of gluteus medius) pedicle bone grafting in neglected femoral neck fracture in physiologically active patients // Indian J. Orthop. 2014. Vol. 48, No. 5. P. 470–475.
29. Mutijima E., De Maertelaer V., Deprez M. [et al.]. The apoptosis of osteoblasts and ostiocytes in femoral head osteonecrosis: its specificity and its distribution // Clin. Rheumatol. 2014. Vol. 33, No. 12. P. 1791–1795.
30. Okazaki S., Nagoya S., Matsumoto H. [et al.]. Development of non-traumatic osteonecrosis of the femoral head requires tolllike receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats // Laboratory Investigation. 2014. Vol. 134. P. 1–8.
31. Peng K.T., Huang K.C., Huang T.W. [et al.]. Single nucleotide polymorphisms other than factor V Leiden are associated with coagulopathy and osteonecrosis of the femoral head in Chinese patients // PloS One. 2014. Vol. 9, No. 8. P. e104461.
32. Rackwitz L., Eden L., Reppenhagen S. [et al.]. Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head // Stem Cell Research and Therapy. 2012. Vol. 3. P. 7–16.
33. Shimatani A., Inori F., Yoshida T. [et al.]. Osteonecrosis of femoral head occurred after stent placement of femoral artery // Case Reports in Orthopedics. 2014. ID 727949, http://dx.doi. org/10.1155/2014/727949.
34. Tian L., Zhou D.S., Wang K.Z. Association of toll-like receptor 4 signaling pathway with steroid-induced femoral head osteonecrosis in rats // J. Huazhong Univ. Sci. Technolog. Med. Sci. 2014. Vol. 34, No. 5. P. 679–686.
35. Vaidyanathan S., Murugan Y., Paulraj K. An unusual complication in osteonecrosis of femoral head: A case report // Hindawi Publishing Corporation Case Reports in Orthopedics. 2013. ID 313289.
36. Venugopal V., Prabhu A., Afshan I. [et al.]. Initial experiences with a new MRI Scoring System for differentiating advanced femoral osteonecrosis from tubercular arthritis // Orthopedics. 2014. Vol. 37, No. 11. P. 1014–1020.
37. Wang W., Liu L., Dang X. [et al.]. The effect of core decompression on local expression of BMP-2, PPAR-Y and bone regeneration in the steroid-induced femoral head osteonecrosis // BMC Musculoskeletal Disorders. 2012. Vol. 13. P. 142–151.
38. Wang C., Peng J., Lu S. Summary of the various treatments for osteonecrosis of the femoral head by mechanism: a review // Exp. Ther. Med. 2014. Vol. 8, No. 3. P. 700–706.
39. Wang C., Wang X., Xu X. [et al.]. Bone microstructure and regional distribution of osteoblast and osteoclast activity in the osteonecrotic femoral head // PLOS One. 2014. doi: 10.1371/ journal.pone. 0096361.
40. Wang X., Qian W., Wu Z. [et al.]. Preliminary screening of differentially expressed circulating microRNAs in patients with steroid-induced osteonecrosis of the femoral head // Mol. Med. Rep. 2014. Vol. 10, No. 6. P. 3118–3124.
41. Wang Z., Zhang Y., Kong X. [et al.]. Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population // Diagnostic Pathology. 2013. Vol. 8. P. 186–192.
42. Wen Q., Jin D., Zhou C. [et al.]. HGF-transgenic MSCs can improve the effects of tissue self-repair in a rabbit model of traumatic osteonecrosis of the femoral head // PLoS ONE. 2012. Vol. 7, No. 5. P. E37503.
43. Wideman R.F., Prisby R.D. Bone circulatory distrubances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis // Frontiers in Endocrinology. Bone research. 2013. Vol. 3. P. 1–14.
44. Yu P.A., Peng K.T., Huang T.W. [et al.]. Injectable synthetic bone graft substitute combined with core decompression in treatment of advanced osteonecrosis of the femoral head: A 5-year followup // Biomed J. 2014. doi:10.4103/2319-4170.138307.
45. Zhang Y., Wang R., Li S. [et al.]. Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population // Diagnostic Pathology. 2013. Vol. 8. P. 169–176.
46. Zhang Y., Wang X., Yang Z. [et al.]. The therapeutic effect of negative pressure in treating femoral head necrosis in rabbits // PLoS ONE. 2013. Vol. 8, No. 1. P. e55745.
47. Zheng H., Yang E., Peng H. [et al.]. Gastrodin prevent steroidinduced osteonecrosis of the femoral head in rats by anti-apoptosis // Chin Med J. 2014. Vol. 127, No. 22. P. 3926–3931.
48. Zheng L., Wang W., Ni J. [et al.]. Plasma interleukin 33 level in patients with osteonecrosis of femoral head: an alarmin for osteonecrosis of the femoral head? // J. Investig. Med. 2014. Vol. 62, No. 3. P. 635–637.

ИЗДАТЕЛЬСТВО: Медицина ДВ

Год основания: 1997  |  Выпусков в год: 4, Статей в выпуске: 30  |  ISSN печатной версии: 1609-1175  |  Подписной  индекс: 18410 (Агентство “Роспечать”)  |  Тираж: 1000 экз.

 

Close Panel